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Archives: Results

Development and Testing of Thrombolytics in Stroke

A new comprehensive review published in Journal of Stroke, written by STROKE BRNO members and our foreign collaborators brings updated information about currently available thrombolytics, strategies for…

Thrombus Imaging Using 3D Printed Middle Cerebral Artery Model and Preclinical Imaging Techniques: Application to Thrombus Targeting and Thrombolytic Studies

Diseases with the highest burden for society such as stroke, myocardial infarction, pulmonary embolism, and others are due to blood clots. Preclinical and clinical techniques to study…

Brno Ph.D. Talent award for Sandra Thalerova

A unique project of cerebral artery models and processes associated with stroke was awarded in Brno Ph.D. talent competition organized by the South Moravian Center for International…

ESO Angels Spirit of Excellence Award for Prof. Robert Mikulík

The ESO Angels Spirit of Excellence award is given to those who embody “perfection in stroke management” in their approach to patients, other hospital team members, and…

Česká hlava for Prof. Jiří Damborský

Together with the Office of the Government of the Czech Republic, Česká hlava is the annual announcer of the same name – the most prestigious Czech award…

Structural Biology and Protein Engineering of Thrombolytics

Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently…

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Introduction of microfluidic mixing technique opens a new door for preparation of the liposomes and lipid-based nanoparticles by on-chip technologies that are applicable in a laboratory and…

Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages

Gadolinium (Gd)–based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier–based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes…

Modification of liposomal surface by polysaccharides: Preparation, characterization, and application for drug targeting

Polysaccharides are important group of compounds used in pharmaceutical industry. Their utilization in formulation of potential nanomedicine drug carriers includes formulation of nanoparticles from polysaccharides itself, encapsulation…

Targeting Human Thrombus by Liposomes Modified with Anti-Fibrin Protein Binders

Development of tools for direct thrombus imaging represents a key step for diagnosis and treatment of stroke. Nanoliposomal carriers of contrast agents and thrombolytics can be functionalized…

From stroke research to treatment


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