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Our Publications

Development and Testing of Thrombolytics in Stroke

A new comprehensive review published in Journal of Stroke, written by STROKE BRNO members and our foreign collaborators brings updated information about currently available thrombolytics, strategies for…

Thrombus Imaging Using 3D Printed Middle Cerebral Artery Model and Preclinical Imaging Techniques: Application to Thrombus Targeting and Thrombolytic Studies

Diseases with the highest burden for society such as stroke, myocardial infarction, pulmonary embolism, and others are due to blood clots. Preclinical and clinical techniques to study…

Structural Biology and Protein Engineering of Thrombolytics

Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently…

Preparation of nanoliposomes by microfluidic mixing in herring-bone channel and the role of membrane fluidity in liposomes formation

Introduction of microfluidic mixing technique opens a new door for preparation of the liposomes and lipid-based nanoparticles by on-chip technologies that are applicable in a laboratory and…

Gadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages

Gadolinium (Gd)–based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier–based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes…

Modification of liposomal surface by polysaccharides: Preparation, characterization, and application for drug targeting

Polysaccharides are important group of compounds used in pharmaceutical industry. Their utilization in formulation of potential nanomedicine drug carriers includes formulation of nanoparticles from polysaccharides itself, encapsulation…

Targeting Human Thrombus by Liposomes Modified with Anti-Fibrin Protein Binders

Development of tools for direct thrombus imaging represents a key step for diagnosis and treatment of stroke. Nanoliposomal carriers of contrast agents and thrombolytics can be functionalized…

Brief analysis of the frequency of use and spectrum of animal models in stroke research

The development of new drugs and curative treatments without animal models is currently not possible. Due to the unique complexity of stroke, the number of models studying…

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow…

Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats.

Olanzapine is a frequently used atypical antipsychotic drug known to exert structural brain alterations in animals. This study investigated whether chronic olanzapine exposure alters regional blood brain…

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